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Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2012-09-06 15:16:51 UTC
Update Date2022-03-07 02:51:54 UTC
HMDB IDHMDB0015200
Secondary Accession Numbers
  • HMDB15200
Metabolite Identification
Common NameGlipizide
DescriptionGlipizide is only found in individuals that have used or taken this drug. It is an oral hypoglycemic agent which is rapidly absorbed and completely metabolized. [PubChem]Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.
Structure
Data?1582753269
Synonyms
ValueSource
1-Cyclohexyl-3-({p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl}sulfonyl)ureaChEBI
AldiabChEBI
CP 28,720ChEBI
CP 28720ChEBI
CP-28,720ChEBI
DigrinChEBI
DipazideChEBI
GlibeneseChEBI
GlibetinChEBI
GlicanChEBI
GlidiabChEBI
GlipidChEBI
GlipizidaChEBI
GlipizidumChEBI
Gluco-riteChEBI
GlucolipChEBI
GlucotrolChEBI
GlucozideChEBI
GlupitelChEBI
GlupizideChEBI
GlydeChEBI
GlydiazinamideChEBI
K 4024ChEBI
MelizideChEBI
MindiabChEBI
MinidabChEBI
MinidiabChEBI
MinodiabChEBI
N-{4-[beta-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulphonyl}-n'-cyclohexylureaChEBI
NapizideChEBI
OzidiaChEBI
SucrazideChEBI
1-Cyclohexyl-3-({p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl}sulphonyl)ureaGenerator
N-{4-[b-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulfonyl}-n'-cyclohexylureaGenerator
N-{4-[b-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulphonyl}-n'-cyclohexylureaGenerator
N-{4-[beta-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulfonyl}-n'-cyclohexylureaGenerator
N-{4-[β-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulfonyl}-n'-cyclohexylureaGenerator
N-{4-[β-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulphonyl}-n'-cyclohexylureaGenerator
Glibenese brand OF glipizideHMDB
GlidiazinamideHMDB
GlypidizineHMDB
Kenfarma brand OF glipizideHMDB
Pfizer brand 2 OF glipizideHMDB
Alphapharm brand OF glipizideHMDB
Lacer brand OF glipizideHMDB
Pfizer brand 1 OF glipizideHMDB
Glipizide kenfarma brandHMDB
Lilly brand OF glipizideHMDB
Chemical FormulaC21H27N5O4S
Average Molecular Weight445.535
Monoisotopic Molecular Weight445.178375067
IUPAC NameN-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-5-methylpyrazine-2-carboxamide
Traditional Nameglipizide
CAS Registry Number29094-61-9
SMILES
CC1=CN=C(C=N1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1
InChI Identifier
InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
InChI KeyZJJXGWJIGJFDTL-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentBenzenesulfonamides
Alternative Parents
Substituents
  • Benzenesulfonamide
  • Benzenesulfonyl group
  • Sulfonylurea
  • Pyrazine
  • Organic sulfonic acid or derivatives
  • Heteroaromatic compound
  • Aminosulfonyl compound
  • Sulfonyl
  • Organosulfonic acid or derivatives
  • Carboximidic acid
  • Carboximidic acid derivative
  • Azacycle
  • Organoheterocyclic compound
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organopnictogen compound
  • Organic oxygen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point208 - 209 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.016 g/LNot Available
LogP2.5Not Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+CBM198.930932474
[M+H]+Not Available196.545http://allccs.zhulab.cn/database/detail?ID=AllCCS00000838
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.016 g/LALOGPS
logP1.83ALOGPS
logP1.43ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)4.32ChemAxon
pKa (Strongest Basic)0.059ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area130.15 ŲChemAxon
Rotatable Bond Count6ChemAxon
Refractivity115.62 m³·mol⁻¹ChemAxon
Polarizability47.64 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+202.57131661259
DarkChem[M-H]-199.47831661259
DeepCCS[M+H]+205.29530932474
DeepCCS[M-H]-202.93730932474
DeepCCS[M-2H]-237.28530932474
DeepCCS[M+Na]+212.26430932474
AllCCS[M+H]+203.832859911
AllCCS[M+H-H2O]+201.732859911
AllCCS[M+NH4]+205.732859911
AllCCS[M+Na]+206.232859911
AllCCS[M-H]-195.532859911
AllCCS[M+Na-2H]-196.532859911
AllCCS[M+HCOO]-197.732859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
GlipizideCC1=CN=C(C=N1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC15042.9Standard polar33892256
GlipizideCC1=CN=C(C=N1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC13102.2Standard non polar33892256
GlipizideCC1=CN=C(C=N1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC14016.1Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Glipizide,1TMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)NC(=O)NC3CCCCC3)C=C2)[Si](C)(C)C)C=N14068.9Semi standard non polar33892256
Glipizide,1TMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)NC(=O)NC3CCCCC3)C=C2)[Si](C)(C)C)C=N13268.5Standard non polar33892256
Glipizide,1TMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)NC(=O)NC3CCCCC3)C=C2)[Si](C)(C)C)C=N15592.8Standard polar33892256
Glipizide,1TMS,isomer #2CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)N(C(=O)NC3CCCCC3)[Si](C)(C)C)C=C2)C=N13942.8Semi standard non polar33892256
Glipizide,1TMS,isomer #2CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)N(C(=O)NC3CCCCC3)[Si](C)(C)C)C=C2)C=N13243.6Standard non polar33892256
Glipizide,1TMS,isomer #2CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)N(C(=O)NC3CCCCC3)[Si](C)(C)C)C=C2)C=N15736.6Standard polar33892256
Glipizide,1TMS,isomer #3CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)NC(=O)N(C3CCCCC3)[Si](C)(C)C)C=C2)C=N13890.7Semi standard non polar33892256
Glipizide,1TMS,isomer #3CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)NC(=O)N(C3CCCCC3)[Si](C)(C)C)C=C2)C=N13274.0Standard non polar33892256
Glipizide,1TMS,isomer #3CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)NC(=O)N(C3CCCCC3)[Si](C)(C)C)C=C2)C=N15692.8Standard polar33892256
Glipizide,2TMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)N(C(=O)NC3CCCCC3)[Si](C)(C)C)C=C2)[Si](C)(C)C)C=N13839.3Semi standard non polar33892256
Glipizide,2TMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)N(C(=O)NC3CCCCC3)[Si](C)(C)C)C=C2)[Si](C)(C)C)C=N13410.9Standard non polar33892256
Glipizide,2TMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)N(C(=O)NC3CCCCC3)[Si](C)(C)C)C=C2)[Si](C)(C)C)C=N15403.8Standard polar33892256
Glipizide,2TMS,isomer #2CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)NC(=O)N(C3CCCCC3)[Si](C)(C)C)C=C2)[Si](C)(C)C)C=N13768.5Semi standard non polar33892256
Glipizide,2TMS,isomer #2CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)NC(=O)N(C3CCCCC3)[Si](C)(C)C)C=C2)[Si](C)(C)C)C=N13433.6Standard non polar33892256
Glipizide,2TMS,isomer #2CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)NC(=O)N(C3CCCCC3)[Si](C)(C)C)C=C2)[Si](C)(C)C)C=N15285.3Standard polar33892256
Glipizide,2TMS,isomer #3CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)N(C(=O)N(C3CCCCC3)[Si](C)(C)C)[Si](C)(C)C)C=C2)C=N13725.6Semi standard non polar33892256
Glipizide,2TMS,isomer #3CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)N(C(=O)N(C3CCCCC3)[Si](C)(C)C)[Si](C)(C)C)C=C2)C=N13474.6Standard non polar33892256
Glipizide,2TMS,isomer #3CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)N(C(=O)N(C3CCCCC3)[Si](C)(C)C)[Si](C)(C)C)C=C2)C=N15407.5Standard polar33892256
Glipizide,3TMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)N(C(=O)N(C3CCCCC3)[Si](C)(C)C)[Si](C)(C)C)C=C2)[Si](C)(C)C)C=N13682.4Semi standard non polar33892256
Glipizide,3TMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)N(C(=O)N(C3CCCCC3)[Si](C)(C)C)[Si](C)(C)C)C=C2)[Si](C)(C)C)C=N13662.5Standard non polar33892256
Glipizide,3TMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)N(C(=O)N(C3CCCCC3)[Si](C)(C)C)[Si](C)(C)C)C=C2)[Si](C)(C)C)C=N14984.1Standard polar33892256
Glipizide,1TBDMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)NC(=O)NC3CCCCC3)C=C2)[Si](C)(C)C(C)(C)C)C=N14314.0Semi standard non polar33892256
Glipizide,1TBDMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)NC(=O)NC3CCCCC3)C=C2)[Si](C)(C)C(C)(C)C)C=N13448.7Standard non polar33892256
Glipizide,1TBDMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)NC(=O)NC3CCCCC3)C=C2)[Si](C)(C)C(C)(C)C)C=N15608.5Standard polar33892256
Glipizide,1TBDMS,isomer #2CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)N(C(=O)NC3CCCCC3)[Si](C)(C)C(C)(C)C)C=C2)C=N14192.7Semi standard non polar33892256
Glipizide,1TBDMS,isomer #2CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)N(C(=O)NC3CCCCC3)[Si](C)(C)C(C)(C)C)C=C2)C=N13430.5Standard non polar33892256
Glipizide,1TBDMS,isomer #2CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)N(C(=O)NC3CCCCC3)[Si](C)(C)C(C)(C)C)C=C2)C=N15735.8Standard polar33892256
Glipizide,1TBDMS,isomer #3CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)NC(=O)N(C3CCCCC3)[Si](C)(C)C(C)(C)C)C=C2)C=N14140.4Semi standard non polar33892256
Glipizide,1TBDMS,isomer #3CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)NC(=O)N(C3CCCCC3)[Si](C)(C)C(C)(C)C)C=C2)C=N13482.0Standard non polar33892256
Glipizide,1TBDMS,isomer #3CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)NC(=O)N(C3CCCCC3)[Si](C)(C)C(C)(C)C)C=C2)C=N15676.4Standard polar33892256
Glipizide,2TBDMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)N(C(=O)NC3CCCCC3)[Si](C)(C)C(C)(C)C)C=C2)[Si](C)(C)C(C)(C)C)C=N14340.8Semi standard non polar33892256
Glipizide,2TBDMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)N(C(=O)NC3CCCCC3)[Si](C)(C)C(C)(C)C)C=C2)[Si](C)(C)C(C)(C)C)C=N13783.8Standard non polar33892256
Glipizide,2TBDMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)N(C(=O)NC3CCCCC3)[Si](C)(C)C(C)(C)C)C=C2)[Si](C)(C)C(C)(C)C)C=N15356.5Standard polar33892256
Glipizide,2TBDMS,isomer #2CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)NC(=O)N(C3CCCCC3)[Si](C)(C)C(C)(C)C)C=C2)[Si](C)(C)C(C)(C)C)C=N14260.3Semi standard non polar33892256
Glipizide,2TBDMS,isomer #2CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)NC(=O)N(C3CCCCC3)[Si](C)(C)C(C)(C)C)C=C2)[Si](C)(C)C(C)(C)C)C=N13827.3Standard non polar33892256
Glipizide,2TBDMS,isomer #2CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)NC(=O)N(C3CCCCC3)[Si](C)(C)C(C)(C)C)C=C2)[Si](C)(C)C(C)(C)C)C=N15223.3Standard polar33892256
Glipizide,2TBDMS,isomer #3CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)N(C(=O)N(C3CCCCC3)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C=C2)C=N14246.7Semi standard non polar33892256
Glipizide,2TBDMS,isomer #3CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)N(C(=O)N(C3CCCCC3)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C=C2)C=N13882.4Standard non polar33892256
Glipizide,2TBDMS,isomer #3CC1=CN=C(C(=O)NCCC2=CC=C(S(=O)(=O)N(C(=O)N(C3CCCCC3)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C=C2)C=N15359.3Standard polar33892256
Glipizide,3TBDMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)N(C(=O)N(C3CCCCC3)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C=C2)[Si](C)(C)C(C)(C)C)C=N14394.9Semi standard non polar33892256
Glipizide,3TBDMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)N(C(=O)N(C3CCCCC3)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C=C2)[Si](C)(C)C(C)(C)C)C=N14250.7Standard non polar33892256
Glipizide,3TBDMS,isomer #1CC1=CN=C(C(=O)N(CCC2=CC=C(S(=O)(=O)N(C(=O)N(C3CCCCC3)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C=C2)[Si](C)(C)C(C)(C)C)C=N14980.2Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Glipizide GC-MS (Non-derivatized) - 70eV, Positivesplash10-0udj-9433200000-0daa174c6f208f739d922017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Glipizide GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide LC-ESI-qTof , Positive-QTOFsplash10-014i-0119600000-895a0f8ef34678f1200d2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide LC-ESI-qTof , Positive-QTOFsplash10-014i-0009600000-3a2ab7e8e725ab4b20902017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide LC-ESI-qTof , Positive-QTOFsplash10-0v4i-3941000000-57ab7532afaad5f9a2ac2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide , positive-QTOFsplash10-014i-0009600000-3a2ab7e8e725ab4b20902017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide , positive-QTOFsplash10-00di-0329000000-a6f7044e9dfe397cfcdd2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide , positive-QTOFsplash10-014i-0119600000-895a0f8ef34678f1200d2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide , positive-QTOFsplash10-00di-1429000000-60bdb648d5355af7a75b2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide , positive-QTOFsplash10-0v4i-3941000000-57ab7532afaad5f9a2ac2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide 60V, Negative-QTOFsplash10-00bc-9400000000-e36d6f6a0eb4114e661c2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide 45V, Negative-QTOFsplash10-00di-3900000000-e23bb49f877be39013202021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide 75V, Negative-QTOFsplash10-004l-9100000000-688c676b3e072ae420712021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide 90V, Negative-QTOFsplash10-01tc-9100000000-4c0399e69298b606717a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide 30V, Positive-QTOFsplash10-0gi9-0946000000-e87ed6360a6302adddaf2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide 60V, Positive-QTOFsplash10-0w30-1900000000-b3353b86c5a5667979952021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide 90V, Positive-QTOFsplash10-01tc-9100000000-1058c878e881b259b2e62021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide 45V, Positive-QTOFsplash10-0gc9-0910000000-97927d7e80b6e6c9c1892021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide 30V, Positive-QTOFsplash10-0gi9-0946000000-1bd55371a0002464d88d2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide 45V, Positive-QTOFsplash10-0gc9-0910000000-4c6c3446c687a5f554692021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Glipizide 60V, Positive-QTOFsplash10-0w30-1900000000-91618f445cb7066cc1912021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Glipizide 10V, Positive-QTOFsplash10-006t-1209300000-c14d0f75f56599ec527f2016-08-02Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Glipizide 20V, Positive-QTOFsplash10-0002-7903000000-63e0326a933897ad8d582016-08-02Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Glipizide 40V, Positive-QTOFsplash10-05mk-9700000000-3dea1f33244b9e19e4072016-08-02Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Glipizide 10V, Negative-QTOFsplash10-0007-5208900000-36b94e0ee176fc17450f2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Glipizide 20V, Negative-QTOFsplash10-00kb-4529000000-18be67f87a3195a21fff2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Glipizide 40V, Negative-QTOFsplash10-0007-9310000000-3bae0e1f24a4fc985c6b2016-08-03Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01067 details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01067 details
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 uMAdult (>18 years old)BothNormalPredicted based on drug qualities
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB01067
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID3359
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkGlipizide
METLIN IDNot Available
PubChem Compound3478
PDB IDNot Available
ChEBI ID5384
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General ReferencesNot Available

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55627.365
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
General function:
Involved in DNA binding
Specific function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis
Gene Name:
PPARG
Uniprot ID:
P37231
Molecular weight:
57619.6
References
  1. Scarsi M, Podvinec M, Roth A, Hug H, Kersten S, Albrecht H, Schwede T, Meyer UA, Rucker C: Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach. Mol Pharmacol. 2007 Feb;71(2):398-406. Epub 2006 Nov 2. [PubMed:17082235 ]
General function:
Involved in ATP binding
Specific function:
Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release
Gene Name:
ABCC8
Uniprot ID:
Q09428
Molecular weight:
177006.4
References
  1. Gribble FM, Ashcroft FM: Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels from beta cells and extrapancreatic tissues. Metabolism. 2000 Oct;49(10 Suppl 2):3-6. [PubMed:11078468 ]
  2. Harrower A: Gliclazide modified release: from once-daily administration to 24-hour blood glucose control. Metabolism. 2000 Oct;49(10 Suppl 2):7-11. [PubMed:11078469 ]
  3. Lawrence CL, Proks P, Rodrigo GC, Jones P, Hayabuchi Y, Standen NB, Ashcroft FM: Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. Diabetologia. 2001 Aug;44(8):1019-25. [PubMed:11484080 ]
  4. Reimann F, Ashcroft FM, Gribble FM: Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 2001 Oct;50(10):2253-9. [PubMed:11574406 ]
  5. Proks P, Reimann F, Green N, Gribble F, Ashcroft F: Sulfonylurea stimulation of insulin secretion. Diabetes. 2002 Dec;51 Suppl 3:S368-76. [PubMed:12475777 ]